The problem is the new security for windows 10 "Ransomware" is blocking Skse64 from working. The solution to fix it is simple just follow these few steps.
Go to Windows Settings.
Click on update & security.
Click Windows Security tab.
Then click Virus & Threat Protection.
Then scroll down to Ransomware Protection.
Click on the Manage ransomware protection.
Click Allow an app through controlled folder access.
Click Add an allowed app.
Click browse all app. Then browse to skse64_loader.exe in your Skyrim installed folder and add it
Now everything should work.
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